Endurance training attenuates the increase in peripheral chemoreflex sensitivity with intermittent hypoxia

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Endurance training attenuates the increase in peripheral chemoreflex sensitivity with intermittent hypoxia.

Patients with heart failure and sleep apnea have greater chemoreflex sensitivity, presumably due to intermittent hypoxia (IH), and this is predictive of mortality. We hypothesized that endurance training would attenuate the effect of IH on peripheral chemoreflex sensitivity in healthy humans. Fifteen young healthy subjects (9 female, 26 ± 1 yr) participated. Between visits, 11 subjects underwen...

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Hyperpnea training attenuates peripheral chemosensitivity and improves cycling endurance.

Well-trained endurance athletes frequently have a lower peripheral chemoreceptor (pR(c)) sensitivity and a lower minute ventilation (E) during exercise compared to untrained individuals. We speculated that the decreased pR(c) response may be specifically associated with repeated exposure to the high rates of ventilation occurring during exercise training. We therefore examined the effect of res...

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Spinal cord injury is associated with enhanced peripheral chemoreflex sensitivity

Sleep-disordered breathing (SDB) is prevalent in individuals with chronic spinal cord injury (SCI), but the exact mechanism is unknown. The aim of this study was to investigate whether peripheral chemoreceptors activity is enhanced in individuals with chronic SCI compared to abled-bodied control subjects using CO2 and O2 chemical tests. In protocol (1) 30 subjects (8 cervical [cSCI], 7 thoracic...

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Peripheral chemoreflex sensitivity and sympathetic nerve activity are normal in apnea divers during training season.

Apnea divers are exposed to repeated massive arterial oxygen desaturation, which could perturb chemoreflexes. An earlier study suggested that peripheral chemoreflex regulation of sympathetic vasomotor tone and ventilation may have recovered 4 or more weeks into the off season. Therefore, we tested the hypothesis that peripheral chemoreflex regulation of ventilation and sympathetic vasomotor ton...

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Hypobaric Intermittent Hypoxia Attenuates Hypoxia-induced Depressor Response

BACKGROUND Hypobaric intermittent hypoxia (HIH) produces many favorable effects in the cardiovascular system such as anti-hypertensive effect. In this study, we showed that HIH significantly attenuated a depressor response induced by acute hypoxia. METHODOLOGY/PRINCIPAL FINDINGS Sprague-Dawley rats received HIH in a hypobaric chamber simulating an altitude of 5000 m. The artery blood pressure...

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ژورنال

عنوان ژورنال: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

سال: 2017

ISSN: 0363-6119,1522-1490

DOI: 10.1152/ajpregu.00105.2016